Polynucleotides (PN), derived from purified salmon DNA, are emerging as one of the most powerful biopolymers in regenerative aesthetics. Initially used in wound healing, their benefits are now transforming skin rejuvenation protocols across the globe. Safe, biocompatible, and highly effective even in delicate areas like the periocular region, polynucleotides are redefining the standards of skin regeneration.
How Polynucleotides Combat Skin Aging
With age, the skin undergoes significant biological changes: collagen production slows, oxidative stress increases, and cellular turnover declines. Polynucleotides offer a multi-targeted solution:
- Stimulate fibroblasts to increase collagen and elastin synthesis
- Reduce inflammation and oxidative stress
- Improve microcirculation and cellular oxygenation
- Enhance hydration and skin texture
- Prevent and correct signs of aging, including fine lines and scars
These actions result in healthier, firmer, and more luminous skin from within — making PN one of the most comprehensive skin bio-revitalizers in aesthetic medicine today.
Clinical Applications & Expert Insights
Polynucleotides are no longer limited to scar and wound management. Recent consensus reports highlight their wide-ranging applications in facial aesthetics:
According to a Korean Dermatologist Survey, the six main indications for PN include:
- Fine lines on the cheeks
- Forehead wrinkles
- Infraorbital and periorbital fine lines
- Uneven skin texture
- Dry, dehydrated skin
An Italian Consensus Report goes further, supporting Polynucleotides use across:
- Face and eye contour
- Neck and décolleté
- Hands and stretch marks
- Scalp (as a regenerative treatment for hair loss)
Polynucleotides are also recognized as ideal skin primers before aesthetic procedures such as lasers, microneedling, and energy-based devices enhancing outcomes and accelerating recovery.
Polynucleotides + Hyaluronic Acid : A Gold-Standard Synergy
Cutting-edge dermboosters now combine Polynucleotides, known as the “diamond of regeneration,” with Hyaluronic Acid, the “gold standard of hydration.” This powerful duo brings both immediate skin hydration and long-term structural repair.
The result? A glowing, elastic, and visibly rejuvenated skin — without the risks of overcorrection or artificial appearance.