A recent peer-reviewed clinical study published in Gels (MDPI, 2025) has confirmed the efficacy and safety of Innovyal Lightening Action, an injectable hydrogel combining hyaluronic acid (HA), niacinamide, and tranexamic acid (TXA). The research demonstrated significant improvements in skin hydration, elasticity, and pigmentation, particularly in darker skin phototypes, highlighting Innovyal’s ability to restore radiance and even tone with outstanding tolerance.
An advanced injectable combining hyaluronic acid (HA), niacinamide, and tranexamic acid (TXA) offers a multifaceted approach to enhancing skin hydration, elasticity, and tone in a single treatment. Clinically evaluated in a prospective trial, this formulation addresses multiple signs of aging with measurable results and excellent tolerability.
These results confirm that Innovyal Lightening Action not only improves brightness and texture but also supports overall skin health and barrier function.
Hyaluronic Acid
Hyaluronic acid delivers deep hydration, enhances elasticity, and provides immediate volumizing effects. It also acts as a carrier matrix for niacinamide and tranexamic acid, enabling their gradual release for prolonged skin quality improvements.
Niacinamide
Niacinamide strengthens the skin barrier, reduces surface roughness, and improves texture. Its antioxidant properties help protect hyaluronic acid chains from oxidative degradation, potentially extending the hydrogel’s longevity and supporting sustained results.
Tranexamic Acid (TXA)
TXA supports dermal structure by aiding collagen synthesis in damaged fibroblasts and contributing to extracellular matrix integrity. It also helps prevent UV-induced pigmentation and hyperpigmentation disorders, working synergistically with hyaluronic acid and niacinamide to enhance and sustain overall skin quality.
This open-label clinical trial enrolled 48 male and female participants aged 18 to 45 years, with Fitzpatrick skin phototypes III to V. The protocol involved two treatment sessions (Day 0 and Day 14), followed by evaluations at Days 28 and 70. Efficacy was assessed using GAIS, Antera 3D imaging, Corneometer, Chromameter, and Cutometer measurements.
Notable outcomes:
“Innovyal Lightening Action represents a new standard in dermatological care. By addressing hydration, elasticity, and pigmentation simultaneously, it offers a truly holistic approach to skin regeneration.”
Innovyal Lightening Action simplifies anti-aging treatments by addressing multiple skin concerns in one injectable protocol, reducing the need for separate procedures. This efficiency, paired with visible and measurable results, offers a compelling option for patients and practitioners seeking comprehensive skin revitalization.
Title: Clinical Evaluation of a Tranexamic Acid–Niacinamide–Hyaluronic Acid Hydrogel in Improving Facial Skin Quality and Radiance
Authors: Dr. Cíntia Marques, Dr. Alexandre Porcello, Dr. Eliza Karska, Dr. Kelly Lourenço, Dr. Nathalie Hirt-Burri, and Prof. Lee Ann Applegate
Published in: Gels (MDPI, 2025)