The delicate under-eye area is often the first to reveal signs of aging, including fine lines, loss of firmness, and dehydration. Addressing this sensitive region requires precision, efficacy, and biocompatibility.
Innovyal Regenerative Action® introduces a breakthrough concept in periorbital prejuvenation through its Regenerative Biopolymers Complex, a unique combination of polynucleotides (PN) and hyaluronic acid (HA)designed to rejuvenate and protect the skin from within.
Developed from advanced regenerative research, Innovyal Regenerative Action® merges the hydrating capacity of HA with the restorative power of PN.
This synergy supports skin cell regeneration, tissue elasticity, and long-term hydration, offering visible improvement in the under-eye region without invasive procedures.
Laboratory studies demonstrated that Innovyal Regenerative Action® outperforms traditional HA-based dermboosters in rheological behavior, ensuring better tissue integration and longer-lasting effects.
In addition, its antioxidant activity helps counteract oxidative stress and prevent premature skin aging, protecting the fragile periorbital tissue from environmental aggressors.
In vitro experiments on human fibroblasts revealed that Innovyal Regenerative Action stimulates collagen synthesis, confirming its biostimulatory potential.
Clinical pilot observations reinforced these results: in two case reports, Innovyal Regenerative Action® improved skin texture, hydration, and fine lines, restoring a radiant, refreshed look around the eyes.
Innovyal Regenerative Action works through a dual mechanism. Polynucleotides trigger cellular renewal and DNA repair, while hyaluronic acid delivers intense hydration and reinforces the extracellular matrix.
This powerful synergy leads to smoother, plumper, and healthier skin, redefining modern under-eye rejuvenation through a naturally regenerative approach.
Innovyal Regenerative Action was injected intradermally (i.e., with a 30-gauge needle) using a multiple micro-aliquot technique.
1.0 mL were applied to each side of the face. The treatment was administered twice with a two-week interval.
Title: Innovyal Regenerative Action, Regenerative Biopolymers Complex for Periorbital Rejuvenation
Authors: Dr. Hanadi Sami Abuyousif , Dr. Alexandre Porcello, Dr. Marco Cerrano, Dr. Cintia Marques, Dr. Corinne Scaletta, Dr. Kelly Louren, Dr. Philippe Abdel-Sayed, Dr. Michèle Chemali, Prof. Wassim Raffoul, Dr. Nathalie Hirt-Burri, Prof. Lee Ann Applegate and Dr. Alexis E. Laurent.
Publisher: MDPI, Polymers Journal, Vol. 17, Issue 5, 2025