At Louna Aesthetics, we are committed to advancing science-based regenerative aesthetics. Today, we highlight a key scientific publication that clarifies the important distinctions between two biomolecules derived from salmon DNA: Polynucleotides (PNs) and Polydeoxyribonucleotides (PDRNs).
While PDRNs have been widely used in aesthetic medicine for their anti-inflammatory and tissue-repairing effects, Polynucleotides (PNs) represent a new frontier with even greater potential. These long DNA chains, with higher molecular weight, offer longer-lasting skin benefits and superior hydration properties.
This publication introduces a new standardized nomenclature based on molecular weight:
PDRN: short DNA fragments, typically under 1500 kDa
PN: longer chains with a molecular weight ≥1500 kDa
This classification called the “Marques Polynucleotide Cutoff”, aims to bring clarity to the often-confused terminology used in regenerative medicine.
Both PDRNs and Polynucleotides are powerful regenerative agents that work on the foundational processes of the skin:
Reduce skin inflammation
Stimulate neoangiogenesis (new blood vessel formation)
Promote fibroblast activation, key to collagen production
Help rebuild the extracellular matrix, improving skin firmness and elasticity
But Polynucleotides go a step further with longer degradation time and enhanced hydration, they offer prolonged and deeper rejuvenation effects.
“Polynucleotide is revolutionizing skin regeneration. It stimulates the complete rebuilding of skin tissue while deeply hydrating for a radiant, glowing look. Plus, it gradually degrades over time, providing sustained skin benefits.”
Dr. Marques, author of the study
This publication is a must-read for any aesthetic professional or scientific expert looking to stay ahead in regenerative technologies.
Read the full article here: https://www.mdpi.com/2218-273X/15/1/148