“Dual Functionalization of Hyaluronan Dermal Fillers with Vitamin B3” investigates the integration of vitamin B3 (niacinamide) into cross-linked hyaluronic acid (HA) fillers, highlighting a dual-functional approach combining hydrogel resilience and bio-stimulation. The study included rheological profiling, oxidative degradation, enzymatic resistance, and dermal fibroblast interaction, demonstrating enhanced resistance to oxidative stress and improved hydrogel stability. In parallel, results showed increased collagen production in dermal fibroblasts, without excessive cellular activation, supporting a balanced regenerative response. These findings contribute to the characterization of injectable biomaterials that combine structural longevity and biological regeneration, providing insight into the relationship between material properties and skin-related biological processes.
In aesthetic medicine, hyaluronic acid (HA) fillers have traditionally been evaluated based on their mechanical properties.
However, real-world performance depends equally on how these materials behave biologically within the skin environment.
A newly published study evaluates the scientific foundation behind LOUNA Fillers, demonstrating how the integration of vitamin B3 (niacinamide) into cross-linked HA creates a dual-functional injectable platform combining structural resilience and intrinsic bio-stimulation.
Enhanced Stability and Interaction with Dermal Fibroblasts
The study assessed LOUNA Fillers through a comprehensive evaluation including rheological profiling, oxidative degradation, enzymatic resistance, and dermal fibroblast interaction.
Results showed enhanced resistance to oxidative stress compared to conventional HA fillers, confirming improved hydrogel stability.
In parallel, both formulations significantly stimulated collagen production in primary dermal fibroblasts.
Importantly, this collagen stimulation occurred without excessive cellular activation, supporting a balanced regenerative response rather than an inflammatory-driven effect.
A Dual Approach Combining Structural Integrity and Skin Regeneration
These findings position LOUNA Fillers within a new category of injectable biomaterials that go beyond volumization.
By reinforcing hydrogel resilience while simultaneously supporting dermal collagen synthesis, vitamin B3 contributes to both durability and skin quality improvement.
This dual mechanism approach addresses two critical dimensions of aesthetic performance:
Such a strategy aligns with the growing demand for treatments that combine immediate correction with long-term tissue support.
This reviewed publication scientifically validates the LOUNA platform concept, supporting its vision of longevity-driven aesthetics grounded in biological understanding.
The data show that LOUNA Fillers combine structural stability with an intrinsic antioxidant effect and a measurable stimulation of collagen production. The study reinforces LOUNA’s positioning at the crossroads of volumization and skin regeneration, uniting material engineering with biological intelligence.
Title: Dual Functionalization of Hyaluronan Dermal Fillers with Vitamin B3: Efficient Combination of Bio-Stimulation Properties with Hydrogel System Resilience Enhancement.
Authors: Porcello A, Chemali M, Marques C, Scaletta C, Lourenço K, Abdel-Sayed P, et al.
Published in: Gels (MDPI, 2024)